A new method for predicting tire rolling impacting noise is presented in this paper. The noise caused by the rolling contact is an important subject in the road transportation industry, which has attracted more and more attention. Unfortunately, at present there is no an effective method to analysis and predict rolling noise. The new method presented in the paper based on the Mixed Lagrange–Euler Method (MLE), by which the velocity field, the acceleration field and the contact deformation of rolling tire with large deformation can be analyzed. Firstly, a 3-D model including the tire pattern and the whole tread is built, by using which the acceleration field of the continuous tire surface is obtained. Then two kinds of tire mesh are developed, one is Lagrange mesh for the rolling tire, and another is Euler mesh fixed in the space which will be used in the noise simulation. And by means of mapping the acceleration of the Lagrange mesh to the Euler mesh, a non-rotational acceleration field is built. At last, by using the aforementioned acceleration field as the acoustic source, the rolling noise can be predicted numerically using FEM. The comparison of the results of test and simulation show that this method is feasible and reasonable. It also proves that the tire rolling noise lower than 1000HZ mostly caused by the impact vibration of the tire pattern. The developed method provided a powerful tool to predict the rolling noise, especially for the patterned tire rolling noise.