Through setting up the diesel locomotive structure-acoustic finite element model, applying the X,Y,Z orientation unite load on the point where the underbed and bogie were connected, the 30Hz~150Hz sound field response was computed. By analyzing the structure-acoustic model, drivers' cab vibration response, acoustical model of cab and cab sound filed response show that the cab sound level has obvious peaks at 68Hz, 76Hz, 86Hz, 98Hz, 124Hz because of the resonance of drivers' cab structure. Due to the structure and acoustical cavity of drivers' cab resonance ,the sound level sharply increase at 98Hz, 124Hz. The conclusion has a good reference value to the drivers' cab vibration and noise reducing.