In order to study the full-band acoustic radiation characteristics of stiffened cylindrical shells, the low frequency calculation model based on FE-BEM method, the mid frequency calculation model based on FE-SEA method, the high frequency calculation model based on SEA method are established in VA-ONE, and which are used to analyze their radiated sound power. The acoustic radiation efficiency of each mode is studied from the view of the inherent mode of the structure. The results show that the reinforcement can reduce the total radiated sound power of the cylindrical shell structure, especially, it can reduce the radiated sound power of the low frequency band. In the middle and low frequency region, the modal radiation efficiency of each mode is very different. In the middle and high frequency region, the difference is not obvious. The influence of the excitation position, shell thickness, material ,constraint conditions and radiation medium on the acoustic radiation characteristics of stiffened cylindrical shell is further studied. In order to reduce the radiated sound power of the stiffened cylindrical shell to the external field, the acoustic optimization design was carried out based on the NCT module and Design Optimization module, The results show that the combination of GA algorithm and SQP algorithm or MMA algorithm can not only reduce the computing time, but also can obtain a better optimization scheme.